Break points in reciprocal autosomal translocations
نویسندگان
چکیده
منابع مشابه
Meiosis in two human reciprocal translocations.
Analysis of meiotic chromosomes from two human male translocation heterozygotes is reported. One had total sterility after maturation arrest and chain configurations at meiosis, and the second had a abnormal children who were presumed to be genetically unbalanced.
متن کاملReciprocal translocations in cattle: frequency estimation.
Chromosomal anomalies, like Robertsonian and reciprocal translocations, represent a big problem in cattle breeding as their presence induces, in the carrier subjects, a well-documented fertility reduction. In cattle, reciprocal translocations (RCPs, a chromosome abnormality caused by an exchange of material between non-homologous chromosomes) are considered rare as to date only 19 reciprocal tr...
متن کاملMeiotic behaviour of two human reciprocal translocations.
The meiotic behaviour of two male human reciprocal translocations is described. One patient had an unbalanced son and a chain configuration. The second had a stillborn child and a ring corresponding to an adjacent I segregation. The meiotic behaviour of chromosomal rearrangements must be investigated for proper genetic counselling.
متن کاملSorting by Reciprocal Translocations via Reversals Theory
The understanding of genome rearrangements is an important endeavor in comparative genomics. A major computational problem in this field is finding a shortest sequence of genome rearrangements that transforms, or sorts, one genome into another. In this paper we focus on sorting a multi-chromosomal genome by translocations. We reveal new relationships between this problem and the well studied pr...
متن کاملEffect of Reciprocal Translocations on Phenotypic Abnormalities
The chromosomal disorders make a significant contribution to human mortality and morbidity. Karyotyping allows the identification of various chromosomes involved in a rearrangement. Chromosomal aberrations occur in approximately 1 in 200 live – born infants and the incidence of reciprocal translocations (rcpts) occur as 1/ 500 live births. Balanced reciprocal translocations can lead to a variet...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2009
ISSN: 0018-0661
DOI: 10.1111/j.1601-5223.1973.tb01113.x